Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis

Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis

碩士 === 中原大學 === 化學研究所 === 105 === Abstract This primary concern of these studys are to explore the researchs on the development of an organocatalytic enantioselective Michael reaction of malononitrile with arylsulfonyl indoles and Friedel-Crafts reaction of α-Naphthol with arylsulfonyl indoles to bu...

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Main Authors: Yueh Pei, 裴樾
Other Authors: Jeng­Liang Han
Format: Others
Language:zh-TW
Published: 2016
Online Access:http://ndltd.ncl.edu.tw/handle/zchg6x
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spelling ndltd-TW-105CYCU50650022019-05-15T23:16:31Z http://ndltd.ncl.edu.tw/handle/zchg6x Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis 利用有機不對稱催化反應合成具有四級碳中心之3,3-雙取代羥吲哚化合物 Yueh Pei 裴樾 碩士 中原大學 化學研究所 105 Abstract This primary concern of these studys are to explore the researchs on the development of an organocatalytic enantioselective Michael reaction of malononitrile with arylsulfonyl indoles and Friedel-Crafts reaction of α-Naphthol with arylsulfonyl indoles to build arylsulfonyl indoles with a quaternary chiral center. These reactions were catalyzed by cinchonidine alkaloid-urea and quinine alkaloid-thourea bifunctional organocatalysts, producing products in yield (up to 86%) and eanntioseletivites (up to 97% ee). Jeng­Liang Han 韓政良 2016 學位論文 ; thesis 206 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 中原大學 === 化學研究所 === 105 === Abstract This primary concern of these studys are to explore the researchs on the development of an organocatalytic enantioselective Michael reaction of malononitrile with arylsulfonyl indoles and Friedel-Crafts reaction of α-Naphthol with arylsulfonyl indoles to build arylsulfonyl indoles with a quaternary chiral center. These reactions were catalyzed by cinchonidine alkaloid-urea and quinine alkaloid-thourea bifunctional organocatalysts, producing products in yield (up to 86%) and eanntioseletivites (up to 97% ee).
author2 Jeng­Liang Han
author_facet Jeng­Liang Han
Yueh Pei
裴樾
author Yueh Pei
裴樾
spellingShingle Yueh Pei
裴樾
Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis
author_sort Yueh Pei
title Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis
title_short Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis
title_full Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis
title_fullStr Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis
title_full_unstemmed Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis
title_sort synthesis of 3,3-disubstituted oxindoles with quaternary center using asymmetric organocatalysis
publishDate 2016
url http://ndltd.ncl.edu.tw/handle/zchg6x
work_keys_str_mv AT yuehpei synthesisof33disubstitutedoxindoleswithquaternarycenterusingasymmetricorganocatalysis
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AT péiyuè lìyòngyǒujībùduìchēngcuīhuàfǎnyīnghéchéngjùyǒusìjítànzhōngxīnzhī33shuāngqǔdàiqiǎngyǐnduǒhuàhéwù
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