Synthesis of 3,3-disubstituted Oxindoles with quaternary center Using Asymmetric Organocatalysis
碩士 === 中原大學 === 化學研究所 === 105 === Abstract This primary concern of these studys are to explore the researchs on the development of an organocatalytic enantioselective Michael reaction of malononitrile with arylsulfonyl indoles and Friedel-Crafts reaction of α-Naphthol with arylsulfonyl indoles to bu...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2016
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| Online Access: | http://ndltd.ncl.edu.tw/handle/zchg6x |
| Summary: | 碩士 === 中原大學 === 化學研究所 === 105 === Abstract
This primary concern of these studys are to explore the researchs on the development of an organocatalytic enantioselective Michael reaction of malononitrile with arylsulfonyl indoles and Friedel-Crafts reaction of α-Naphthol with arylsulfonyl indoles to build arylsulfonyl indoles with a quaternary chiral center.
These reactions were catalyzed by cinchonidine alkaloid-urea and quinine alkaloid-thourea bifunctional organocatalysts, producing products in yield (up to 86%) and eanntioseletivites (up to 97% ee).
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