The study of Electrostatic Hazard and Improvement at the Organic Chemosynthesis Workplace of Active Pharmaceutical Ingredients Manufacturer

• Main Authors: SHEN,YU-TING, 沈育廷
• Other Authors: LIU,YUH-WEHN
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/08843812627056086120

碩士 === 嘉南藥理大學 === 職業安全衛生系 === 105 === The industry of active pharmaceutical ingredients includes organic chemosynthesis, extraction and purification from the natural products, fermentation of microbes or semisynthesis after fermentation. The main process technologies are recall, extraction, isolation, purification, and preparation formula. For the preparation of the general chemical products, the main process technologies contain the complicated organic synthesis, isolation and purification. The active pharmaceutical ingredients include the general chemical products, extraction from the animals or plants, strains of the microbes, fermentation, and genetic engineering or the protein-related tissue cells of cell hybridization etc., and among all, the chemical products represent for the majority. Static electricity is one of the natural phenomena in the nature for most materials are possibly able to create static electricity. With the fact that the static electricity may be created by having two surfaces of different materials friction, contact and separate, most people will have the chance to feel the static electricity. Among the industries of chemical, petrochemical, coating, plastic, printing, or electronics, it is not rare to find the electrostatic hazard problems caused fire explosion which leads to staff casualty and property damages. Consequently, the problems of electrostatic hazard as well as the hazardous accidents caused are gradually catching more and more attention from the public. This research is to take a domestic active pharmaceutical ingredients manufacturer as an example for case study and to investigate the electrostatic hazard and improvement at the organic chemosynthesis workplace. For the operational processes at the organic chemosynthesis workplace, the risk analysis method, Preliminary Hazard Analysis (PHA) is applied and to analyze the operational processes at the organic chemosynthesis workplace from the angle of PHA and the hazardous risk assessment is implemented to analyze the electrostatic hazard of every single operational process. With the analysis results of PHA in all of the operational processes at the organic chemosynthesis workplace, this workplace is defined as the high risk area of electrostatic hazard. For the hazard with higher hazardous risk level, improvement and prevention shall be implemented in order to decrease the risk level as well as probability of hazard occurrence so that the risk of electrostatic hazard can also be reduced to the acceptable level.