Selection of The Potential Anti-prostate Cancer Drugs and Gene

• Main Authors: Zhang, Cheng-Yu, 張澄羽
• Other Authors: Hung, Jui-Hsiang
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/zpx384

碩士 === 嘉南藥理大學 === 生物科技系 === 105 === Prostate cancer is one of the top ten cancer causes in the Ministry of Health department of Taiwan's statistics, and the second major cause of male cancer death in 2016 on the United States. The risk of having prostate cancer will increase with the age. Prostate cancer treatments are mainly included surgical resection, radiation therapy, cryotherapy and hormonal treatment, but we still need to find more effective treatments and drugs for against the population aging and mortality. In this study, we analyze the potential target gene by using bioinformatics and focus on research the potential drugs. In the bioinformatics analysis, overexpression of PDLIM5 in prostate cancer was determined by using Oncomine database. In addition, poor survival rate in PDLIM5 overexpression prostate cancer patients were observed form Survnexpress, PROGeneV2, PrognoScan and Cancer Cell Line Encyclopedia (CCLE) database. We analyzed 27 compounds and the results showed that compound No. 7 had better effects on prostate cancer cell lines LNCaP and PC-3 cells. Therefore, in the further study, we will try to investigate the signaling pathways of compound No. 7 and the role of PDLIM5 in prostate cancer cells. These results will be helpful on developing the potential drugs.