| Summary: | 碩士 === 中華科技大學 === 健康科技研究所 === 105 === The electrospinning technique was used to fabricate poly(vinyl alcohol) (PVA)/chitosan (CS) nanofibers containing rutin. Scanning electron microscopy (SEM) was used to characterize the surface morphology of the PVA/CS-rutin nanofibrous mats and their average diameters ranged from 150 to 200 nm depending on the electrospinning parameters. Water vapor transmission rate (WVTR) and equilibrium water content (EWC) of these PVA/CS-rutin nanofibrous mats were assessed and the results were in the desired range for wound dressings. The antioxidant activities of PVA/CS-rutin nanofibrous mats were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferrous iron chelating and total phenolic content assays. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay confirmed the cytotoxicity of PVA/CS-rutin nanofibrous mats against L929 fibroblast cells. The PVA/CS-rutin nanofibrous mats offer a great potential for wound dressing applications.
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