Microdosimery study of gold atom RBE enhancement using a Miniature Tissue Equivalent Proportional Counter
碩士 === 長庚大學 === 醫學影像暨放射科學系 === 105 === In the past decade, many study has shown that the gold nanoparticles (GNPs) have the potential to be a radio-sensitizer in radiation therapy. The radiation enhancement by GNPs is achieved by dose and radical from induced Auger electrons. Nowadays, there is no m...
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| Format: | Others |
| Language: | zh-TW |
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2017
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| Online Access: | http://ndltd.ncl.edu.tw/handle/r9yt8x |
| Summary: | 碩士 === 長庚大學 === 醫學影像暨放射科學系 === 105 === In the past decade, many study has shown that the gold nanoparticles (GNPs) have the potential to be a radio-sensitizer in radiation therapy. The radiation enhancement by GNPs is achieved by dose and radical from induced Auger electrons. Nowadays, there is no microdosimetry measurement for the radiation quality enhancement of GNPs in photon radiation. This study used a homemade mini-TEPC in the Chang Gung University (CGU) microdosimetry laboratory to simulate a subcellular target with 1 µm and 0.1 µm diameter irradiated by 192Ir and 250 kVp X-ray photons. This mini-TEPC was used to measure microdosimetry spectra and ready for radiation quality and RBE analysis. A plug with 50 nm thickness of GNPs coating was inserted into the hole on the mini-TEPC. The relative biological effectiveness (RBE) of Human Salivary Gland tumor at the 10% survival level was evaluated by MK model through the relationship between dose mean lineal energy (y ̅_D) and RBE. Microdosimtric analysis results show that the radiation enhancement effects of GNPs caused by y ̅_D increased by 16% and RBE increased by about 4% in the 1 µm subcellular target under 250 kVp X-ray irradiation conditions. For the assessments of the mini-TEPC irradiated by 192Ir, however, the radiation quality enhancement effects of GNPs shows no significant enhancements. This study has demonstrates the feasibility of microdosimetric measurements in photon radiations and evaluated the radiation enhancement of GNPs from the microdosimetric point of view.
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