Evaluation of Bone Mineral Density in healthy examination populations: A Three- Year longitudinal study

• Main Authors: CHENG, SU- MIN, 鄭素敏
• Other Authors: KUO, CHIUNG- WEN
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/3h8xr4

碩士 === 元培醫事科技大學 === 醫學影像暨放射技術系碩士在職專班 === 104 === Evaluation of Bone Mineral Density in healthy examination populations: A Three- Year longitudinal study Student：Su-Min Cheng Advisor：Chiung-Wen Kuo, Ph. D. Institute of Medical Imaging and Radiological Technology Yuanpei University of Medical Technology Abstract The purpose of this study was to investigate the effect of serum biomarkers on bone mineral density (BMD) in three years longitudinal study. A total of 290 subjects (232 males and 58 females), aged 26 to 46 years were enrolled from 2012 to 2015. Measurements of BMD were performed using dual- energy X-ray absorptiometry at L2- L4. Serum was collected including cholesterol, triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), glucose, aspartate aminotransferase (AST), and alanine aminotransferase (ALT). In stepwise regression analysis analyses, the body weight was positively associated with BMD (β = 0.002, p < 0.05) and ALT was negatively associated with BMD (β = -0.001, p < 0.05).This retrospective study still had some limitations. The study showed that the longitudinal tracking study in those measurements of bone mineral density is necessary for further changes. Further experimentation is necessary in order to understand the exact mechanisms involved. Our results suggested low body weight and high ALT were deleterious factor on BMD. Keywords: bone mineral density (BMD), alanine aminotransferase (ALT), dual- energy x-ray absorptiometry