Development of Gastric Floating Drug Delivery Systems for Hydroxypropyl Methylcellulose Stearoxy Ether

• Main Authors: Huang Jheng-Kai, 黃鉦凱
• Other Authors: Lin Hong-Liang
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/35761865526261537107

碩士 === 元培醫事科技大學 === 生物科技暨製藥技術系碩士班 === 104 === Hydroxypropyl methyl cellulose has a viscosity, swelling and gel properties commonly used in the development of the floating gastric retentive dosage form. The hydroxypropyl methyl stearyl ether oxygen having a ratio characteristics, although hydroxypropylmethyl cellulose, but has yet to Hydroxypropyl methyl stearyl ether oxygen and hydroxypropylmethylcellulose formulations developed floating in gastric retentive, therefore, this study will evaluate it. The results of swelling test series B and hydroxypropylmethyl cellulose 4K, hydroxypropyl methyl proportion stearyl ether oxygen content 60L 1: 1, 3: 1 and hydroxypropyl methyl cellulose and hydroxypropylmethyl hard 15K 60L oxygen ether lipid content ratio of 2: 1 expansion performance is more significant. The series C and hydroxypropylmethyl cellulose 4K, hydroxypropyl methyl proportion stearyl ether oxygen content 90L 1: 1 and hydroxypropyl methyl cellulose and hydroxypropylmethyl 15K stearyl ether 90L oxygen content ratio 2: 1 expansion relatively good performance. And ciprofloxacin-dimensional mode preparation of a medicament floating gastric retentive dosage forms. Our results in the first 8 hours B1-3 measured expansion ratio of 387.9%, R2 value of 0.992; B2-2 in the first eight hours measured expansion rate of 339.1%, R2 value of 0.985; C2-2 in the first 8 hours measured expansion rate of 339.3%, R2 value of 0.982, the drug release profile close to zero order release, and the floating time up to 24 hours. The result aggregated Conclusion: hydroxypropyl methyl stearyl ether oxygen can not be fully substituted hydroxypropyl methyl cellulose prepared in the gastric retention drug delivery system, because the solution into a lozenge; showed within about 90 seconds, showing completely disintegrated. This hydroxypropylmethyl stearyl ether oxygen can not be fully substituted hypromellose prepared drug formulations in the stomach, but can be reduced to the ingot prepared using higher viscosity hypromellose dosage. By experimental results with hydroxypropyl methylcellulose and hydroxypropyl methyl stearyl ether oxygen can be prepared in a common floating gastric retentive dosage form, and have a good drug release mechanism and follows zero-order release.