| Summary: | 博士 === 國立陽明大學 === 腦科學研究所 === 104 === The aim of this study is to evaluate vestibular autorotation test (VAT) and alternatingly horizontal head impulse test (HIT) with an electronic gyrometry and low-power radiofrequency (RF) wireless data transmission and new analytic technique. Signals of electro-oculography (EOG) and head movements are sampled and acquired digitally at the same time and the data are transmitted to a laptop wirelessly. After using digital signal processing of the eye movement signals and the head motion/rotation signals, different analytic methodology, such as correlation analysis (cross correlation coefficient, CCC) and chaos analysis (approximate entropy, ApEn), were applied to represent a quantitative index of the vestibular functions.
First, a correlational-VAT (cVAT) system was developed to evaluate the aging of vestibular function. Age was significantly and negatively correlated with the mean CCC for all test conditions, including horizontal or vertical autorotations with open eyes or closed eyes. Then, this cVAT system to patients with peripheral vestibulopathies was applied to evaluate the reliability and applicability of this system. The vertiginous participants had significantly lower individual CCCs and an overall mean CCC than age-and-gender matched controls. This cVAT had good test-retest reliability for both studies of age and patients.
Finally, the complexity of vestibular-ocular reflex (VOR) in patients with acute vestibular neuritis by saccadic entropy of head impulses was evaluated. Mean VOR gain and mean ApEn of the lesion-side HIT were significantly different from those of the non-lesion side and control group. Additionally, the mean ApEn of the non-lesion-side HIT was significantly greater than the control group. VOR gain of the non-lesion- side HIT and control group was no significantly different. So ApEn is better than VOR gain to detect the VOR function deficits of non-lesion side of HIT.
This sensor system and analytic methodology has the following advantages. Minimal sensor slippage during high-speed head turn was found because of a small sensor and a wireless transmission technique. There was good test-retest reliability.
In conclusion, the correlational VAT system has good test-retest reliability. The cVAT can reveal the decline of vestibular function with age and it is also able to efficiently detect peripheral vestibulopathies. Saccadic entropy of HIT could be used to detect the VOR dysfunctions of acute vestibular neuritis and may become effective methods for detecting and evaluating vestibular disorders.
|
|---|
