| Summary: | 碩士 === 大同大學 === 材料工程學系(所) === 104 === Development of biocompatible and multifunctional nanocarrier plays an important role for the therapeutic efficacy of drug in the treatment of disease. Mesoporous materials have much attention as drug storage and release cargo due to their unique surface and textural properties. Due to most hepatocellular carcinoma (HCC) may overexpressing glypican-3 (GPC3), so it can immobilization GPC3 antibody onto nanoparticle surface to active targeting tumor cell, as further enhance cell uptake. In this study, we successfully synthesized mesoporous hydroxyapatite doping with iron (mHapFe) through simple one-step co-precipitation process. From the results, the mHapFe nanoparticles keep Hap lattice structure and have rod-like morphology with superparamagnetic property. The size of nanoparticles is around 60-80 nm in length and 20 nm in width. High surface area (126.32 m2/g) and pore volume (0.82 cm3/g) distribution of mHapFe NPs enhance drug loading and abhesion efficiency. The mHapFe NPs not only have good biocompatibility but also demonstrate sustained release profile. Besides, mHapFe structure could be disrupted by applied high-frequency magnetic field (HFMF) for controlling burst and trigger release. It indicated that mHapFe NPs have a great potential as triggered drug delivery nanocarrier for biomedical applications. Finally, it can using chemohyperthermia that hyperthermia improves the antitumor effect of some chemotherapeutic agents.
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