Using NHIRD and Taiwan Cancer Registry to Analyze the Relationship Between Insulin and the Risk of Cancer with Diabetes

• Main Authors: Shih-Ting Wang, 王詩婷
• Other Authors: Hung-Wen Chiu
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/01383322582507027544

碩士 === 臺北醫學大學 === 醫學資訊研究所 === 104 === Background: Recent studies have suggested that some insulin analogs could be associated with an increased risk of cancer. The aim of this dissertation is to examine whether patients with diabetes mellitus (DM) using insulin have a higher risk of cancer in comparison to patients using other types of therapy. Objectives: This dissertation first will estimate the risk of cancer on diabetes with insulin therapy and non-insulin therapy. Secondly, estimate the risk of cancer on insulin using more than 2 years, and under 2 years. Methodology: This dissertation used the National Health Insurance Research Database (NHIRD) that covers the majority of Taiwan population with diagnosed diabetes, and examined patients with diabetes who were exposed to any insulin therapy between 1 January 2001 and 31 December 2003. This dissertation defined two cohorts, patient with insulin therapy as the experimental samples, and non-insulin therapy as control samples. Record from these cohorts were linked to cancer registry data up to the end of 2009. Then use Chi-square test to analyze their risk of cancer. Results: Within five years, the risk of cancer associated with the use of insulin is still not well defined. Also, long term (over 2 years) use of insulin does not appear to increase the risk of cancer.