Using micro-osteoperforation and corticision for accelerating orthodontic tooth movement in rats

• Main Authors: Hsueh-Yin Hsieh, 謝學吟
• Other Authors: Chi-Yang Tsai
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/56903621620535029821

碩士 === 臺北醫學大學 === 牙醫學系碩博士班 === 104 === <Objectives>: In vivo studies have revealed significant and nonsignificant differences in the rate of orthodontic tooth movement after micro-osteoperforation and corti-cision. Because most studies have been performed under different condition, their results are incomparable. We compared the 2 surgical approaches—micro-osteoperforation and corti-cision—without flap elevation under identical conditions. Furthermore, we combined the 2 approaches to determine whether increasing surgical trauma increases the rate of tooth movement. <Materials & Methods>: 60 male adult Sprague-Dawley rats were enrolled at 8 weeks of age, and upper left first molars were pulled forward by orthodontic appliance from upper incisors with a force of 50-g. Three kinds of surgical interventions were conducted in Group 1 to 4: micro-osteoperforation (MOP + F), corti-cision (C + F), micro-osteoperforation + corticision (MOP + C + F), and or-thodontic force only (control; F). The experimental duration was 6 weeks, and distance and velocity of tooth movement, bone density, and osteoclasts were analyzed. <Results>: Application of the three flapless minor surgeries reduced bone density and significantly increased osteoclastic activity at week 3 and increased tooth movement and velocity at week 2. The three flapless minor surgeries showed no significant difference in tooth movements, bone density and osteoclastic activity in rats. <Conclusions>: With the three flapless minor surgeries, it had increased amount and rate of tooth movement during the early stage. Tooth movement rate and the un-derlying bone density and osteoclasts number did not increase proportion-ally with surgical trauma; however, the increase in tooth movement velocity lasted longer.