Synthesis of potentially Positron Emission Tomography active compounds

• Main Authors: Yung-Yu Lin, 林勇宇
• Other Authors: 李世元
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/91090534788995427736

碩士 === 淡江大學 === 化學學系碩士班 === 104 === The Positron Emission Tomography (PET) is a nuclear medical inspection technology. Recently, it was further applied to observe the cell metabolism, protein synthesis and psychiatric diseases and to find out proper treatments for some diseases. Making PET more accurate for detecting tumor growth scenario diagnosis, it is widely used PET for tumor imaging technology which is based on normal cells can absorb. glucose and them accumulate to certain level that PET really detects. Thus, PET way play a key role in drugs research and development. The integrin avb3 receptor relies on the surface of tumor angiogenesis endothelial cells and the tumor cells. It has been confirmed that the integrin avb3 receptor plays an important role of angiogenesis. Therefore, we design and synthesis non-radiopharmaceutical 4-nitrophenyl-2-bromopropionate (NBP) compound as precursor of radiolabelled 4-nitrophenyl-2-[18F]Fluoropropionate (18F-NFP) compound. Both NBP and NFP could be easily synthesized by amidation reaction of α-halopropionate with p-nitrophenol by using 1-(3-Dimethylaminopropyl)- 3-ethyl-carbodiimide ( EDC ) as coupling reagent