| Summary: | 碩士 === 國立臺北科技大學 === 機電整合研究所 === 104 === The study presents a biosensor based on the dental implant structure including a tri-electrode and circuit design, a modified electrode approach and a wireless bluetooth module that can replace the currently invasive methods for blood glucose sensing. Before the tri-electrode circuit design, the controlled bias should be verified by cyclic voltammetry measurements and the most linear relationship between the glucose concentration and the current variation is 0.6V. In addition, the enzyme and glucose are expected to interact violently at this point; therefore, the tri-electrode circuit was designer according to the controlled bias. In order to enhance the sensor characteristics, some modification techniques were applied to the working electrode, such as the use of a rough electrode and a graphene-added electrode. Additionally, the sensing electrode was protected by a polymer dialysis membrane to avoid impurities or large molecules that may affect the lifetime of the enzyme. In summary, the graphene electrode has the best sensing characteristics such as the optimal sensitivity of 400 uV/(mg/dl), the lowest detection limit of 0.527mg/dl and at least fifteen hours of operation time to work. Finally, the biosensor was integrated to a bluetooth 4.1 module which is able to convert analog-to-digit signals, exhibiting a highly linear translation between the digital signal and glucose concentrations.
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