Design and Evaluate of an Intraoral Piezoelectric Drug Delivery Device for Long-Term Drug Release

• Main Authors: Tzi-Kuan Lu, 呂子寬
• Other Authors: 呂志誠
• Format: Others
• Language: zh-TW
• Online Access: http://ndltd.ncl.edu.tw/handle/dc24uf

碩士 === 國立臺北科技大學 === 製造科技研究所 === 104 === The goal of this paper is to implement a drug delivery device into a titanium dental implant which achieves drug release to chronic patients maxillary bone. The device can provide a non-disposable and invasive therapy treatment approach, and also offer painless and long-term painless drug release.This thesis can contain several parts. The first part is the drug delivery device design. The second is the use of Ansys to simulate the fluid-solid coupling effect of a valveless piezoelectric micropump and obtain the device characteristics. The final part is polymer drug release experiment. In the drug delivery device design, compared with the previous laboratorys design and results, the implant volume was reduced more than 50%. Compared with a valve micropump, the valveless pump structure is simple and far from mechanical impact damage. From the driving voltage and frequency measurement in piezoelectric micropump , it is found that when applied voltage frequency of 60 Hz, the micropump can have a maximum flow rate of 0.015 g/s at 30 V, and up to 0.025 g/sat 40 V. For the driving voltage, when the applied voltage is higher, the flow rate is also increased. In addition, the use of Ansys CFX modules can evaluate the valveless piezoelectric pump, simulate the piezoelectric vibration modes which is transmitted into the piezoelectric membrane, find out the change of chamber internal pressure with respect to the flow rate change, and verify the valveless piezoelectric micropump. The study also provide a mechanical mechanism for macromolecular or polymetric drug release. Finally the assessment on the continuous and long-term drug release device is successfully completed.