Mesoporous iron particle for hemoglobin deficient

• Main Authors: Yu-Jyun Liao, 廖昱鈞
• Other Authors: Jhewn-Kuang Chen
• Format: Others
• Online Access: http://ndltd.ncl.edu.tw/handle/38y2d5

碩士 === 國立臺北科技大學 === 材料科學與工程研究所 === 104 === The number of chronic kidney disease patients has increased rapidly because of the economic development in the world, and chronic kidney disease has also become a severe health and socio-economic crisis. Chronic kidney disease causes a great impact on other organs as well. However, this study mainly focuses on iron deficiency anemia which is caused by chronic kidney disease for the therapeutic direction. Since most iron supplements in the market are flooded with divalent iron, which is too strong for patients with gastrointestinal side effects. To reduce the burden of chronic kidney disease patients, we develop a zero-valent iron to reduce the side effect and use it for iron deficiency anemia treatment. Mesoporous zero-valent irons structure increase the specific surface area which increasing the absorption efficiency in the gastrointestinal. The study uses chemical reduction method to produce mesoporous zero-valent iron. We successfully prepared mesoporous zero valent iron by using polyvinyl alcohol as a foaming agent, tween80 and span80 as surfactants, and the reaction is in the oil phase. The zero-valent iron has good biocompatibility and low toxicity.