Recrystallization of Mefenamic Acid Using Sonocrystallization Process

• Main Authors: tsai,yi-chen, 蔡宜蓁
• Other Authors: 蘇至善
• Format: Others
• Online Access: http://ndltd.ncl.edu.tw/handle/n778bj

碩士 === 國立臺北科技大學 === 化學工程研究所 === 104 === In the study, cooling sonocrystallization process was used to recrystallize an active pharmaceutical ingredient (API), mafenamic acid. Prior to crystallization study, solid solubilities of mafenamic acid in four organic solvents including methyl ethyl ketone, methanol,acetonitrile, and tetrahydrofuran at 278.2 K to 328.2 K were measured and correlated. In cooling sonocrystallziation, solvent effect was firstly invistagated and ethyl acetate is selected as an appropriate solvent system to further study the effects of solution concentration, sonicated intensity, solution flow rate, and cooling rate. At optimizing condition, mafenamic acid crystals with mean size of 15 μm were obtained from its original 36 μm. Furthermore the physical and chemical properties is analyzed by scanning electron microscope (SEM), X-ray powder diffraction, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and these properties are unchanged .