Absolute bioavailability of 2,4,5-Trimethoxybenzaldehyde

碩士 === 實踐大學 === 食品營養與保健生技學系碩士班 === 104 === 2,4,5-trimethoxybenzaldehyde (2,4,5-TMBA) is a bitter principle present in plant seeds, roots, and leaves. In our previous study, 2,4,5-TMBA suppresses differentiation of preadipocytes into adipocytes and enhances lipolysis in mature adipocytes. This study...

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Main Authors: Yi-Kai Wu, 吳毅凱
Other Authors: Fannie C. F. Kuo
Format: Others
Language:zh-TW
Published: 2016
Online Access:http://ndltd.ncl.edu.tw/handle/49705761844497525774
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spelling ndltd-TW-104SCC002550012017-08-12T04:35:08Z http://ndltd.ncl.edu.tw/handle/49705761844497525774 Absolute bioavailability of 2,4,5-Trimethoxybenzaldehyde 胡蘿蔔子素2,4,5-TMBA之絕對生物可利用率 Yi-Kai Wu 吳毅凱 碩士 實踐大學 食品營養與保健生技學系碩士班 104 2,4,5-trimethoxybenzaldehyde (2,4,5-TMBA) is a bitter principle present in plant seeds, roots, and leaves. In our previous study, 2,4,5-TMBA suppresses differentiation of preadipocytes into adipocytes and enhances lipolysis in mature adipocytes. This study aimed to investigate the bioavailability, pharmacokinetics, and excretion of 2,4,5-TMBA in nine-week old Sprague-Dawley rats. After oral administration of 100 mg/kg 2,4,5-TMBA, the Cmax (maximum concentration), AUC (area under curve), Tmax (time of maximum concentration), and T1/2 (time required for half of the maximum concentration) were calculated as 3.51±1.17 μg/mL, 116.10±62.49 μg/mL, 18.33±4.08 min, and 28.10±9.72 min, respectively. After intravenous administration of 10 mg/kg 2,4,5-TMBA, the Cmax, AUC, and T1/2 were calculated as 2.19±0.99 μg/mL, 18.49±15.06min, and 7.03±2.77 min, respectively. The bioavailability of 2,4,5-TMBA was estimated as 62.77% based on the AUCs of oral and IV administration. Half hour after oral administration, 2,4,5-TMBA reached the highest concentration of 211.661 μg/g in stomach. In one hour, 2,4,5-TMBA reached the highest concentrations in heart, liver, kidney, small intestine, and large intestine as 0.472±0.709, 0.460±0.754, 0.302±0.482, 7.087±11.886, and 1.363±2.134 μg/g, respectively. The concentrations of 2,4,5-TMBA in urine were 0.468±0.261, 0.181±0.079, 0.136±0.077, and 0.046±0.047 μg/mL at 0-4, 4-8, 8-12, and 12-24 hours after oral administration, respectively. The amounts of 2,4,5-TMBA in feces were 0.721±1.255, 0.131±0.136, 0.621±1.193, and 0.039±0.018 μg/g at 0-4, 4-8, 8-12, and 12-24 hours after oral administration, respectively. Fannie C. F. Kuo 郭家芬 2016 學位論文 ; thesis 75 zh-TW
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description 碩士 === 實踐大學 === 食品營養與保健生技學系碩士班 === 104 === 2,4,5-trimethoxybenzaldehyde (2,4,5-TMBA) is a bitter principle present in plant seeds, roots, and leaves. In our previous study, 2,4,5-TMBA suppresses differentiation of preadipocytes into adipocytes and enhances lipolysis in mature adipocytes. This study aimed to investigate the bioavailability, pharmacokinetics, and excretion of 2,4,5-TMBA in nine-week old Sprague-Dawley rats. After oral administration of 100 mg/kg 2,4,5-TMBA, the Cmax (maximum concentration), AUC (area under curve), Tmax (time of maximum concentration), and T1/2 (time required for half of the maximum concentration) were calculated as 3.51±1.17 μg/mL, 116.10±62.49 μg/mL, 18.33±4.08 min, and 28.10±9.72 min, respectively. After intravenous administration of 10 mg/kg 2,4,5-TMBA, the Cmax, AUC, and T1/2 were calculated as 2.19±0.99 μg/mL, 18.49±15.06min, and 7.03±2.77 min, respectively. The bioavailability of 2,4,5-TMBA was estimated as 62.77% based on the AUCs of oral and IV administration. Half hour after oral administration, 2,4,5-TMBA reached the highest concentration of 211.661 μg/g in stomach. In one hour, 2,4,5-TMBA reached the highest concentrations in heart, liver, kidney, small intestine, and large intestine as 0.472±0.709, 0.460±0.754, 0.302±0.482, 7.087±11.886, and 1.363±2.134 μg/g, respectively. The concentrations of 2,4,5-TMBA in urine were 0.468±0.261, 0.181±0.079, 0.136±0.077, and 0.046±0.047 μg/mL at 0-4, 4-8, 8-12, and 12-24 hours after oral administration, respectively. The amounts of 2,4,5-TMBA in feces were 0.721±1.255, 0.131±0.136, 0.621±1.193, and 0.039±0.018 μg/g at 0-4, 4-8, 8-12, and 12-24 hours after oral administration, respectively.
author2 Fannie C. F. Kuo
author_facet Fannie C. F. Kuo
Yi-Kai Wu
吳毅凱
author Yi-Kai Wu
吳毅凱
spellingShingle Yi-Kai Wu
吳毅凱
Absolute bioavailability of 2,4,5-Trimethoxybenzaldehyde
author_sort Yi-Kai Wu
title Absolute bioavailability of 2,4,5-Trimethoxybenzaldehyde
title_short Absolute bioavailability of 2,4,5-Trimethoxybenzaldehyde
title_full Absolute bioavailability of 2,4,5-Trimethoxybenzaldehyde
title_fullStr Absolute bioavailability of 2,4,5-Trimethoxybenzaldehyde
title_full_unstemmed Absolute bioavailability of 2,4,5-Trimethoxybenzaldehyde
title_sort absolute bioavailability of 2,4,5-trimethoxybenzaldehyde
publishDate 2016
url http://ndltd.ncl.edu.tw/handle/49705761844497525774
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