| Summary: | 碩士 === 國立臺灣科技大學 === 機械工程系 === 104 === Integration a filter into a microfluidic chip with the benefit from the easily selecting of the pore size due to the availability of the market was approached and reported from various studies. One of the major drawbacks of this approach is the leakage between the filter and the polymeric microfluidic chip/microchannel therefore a novel assembly approach to create a microfluidic chip with embedding the filter for sample separation without the leakage was conducted in this study The microchannel was fabricated on the PMMA substrates and the polycarbonate-based filter was sandwiched between PMMA substrates. The bonding between the PMMA substrates was based on UV glue, the UV glue was injected into a designed ring structure around the filter to prevent the leakage across the edge of the filter. Spiral microchannel geometry was designed to improve the flow situation in the flow channel, reducing ineffective filtration area. Several microfluidic chips with various pore size filters were fabricated for experiments. In order to test the functionality of the fabricated chip, various experiments including the bonding strength test, filtration pressure measurement and blood separation experiment were conducted.
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