| Summary: | 碩士 === 國立臺灣科技大學 === 化學工程系 === 104 === The objective of the present study is to measure the equilibrium solubilities of 2nd generation sulfonylureas（gliquidone and gliclazide）in supercritical CO2 with a semi-flow type equilibrium apparatus at temperatures ranging from 313.2 K to 353.2 K and pressure from 15 MPa to 31 MPa. To ensure the output stream of equilibrium cell being saturated, the minimum contact time are 1700（s）and 1300（s）for gliquidone and gliclazide, respectively. Over the experimental conditions, solubilities are ranging from 0.049 x 10-5 ~ 1.88 x 10-5 for gliquidone, 0.55 x 10-5 ~ 4.7 x 10-5 for gliclazide. The solubility data are correlated with two semi-empirical density-based model, including the Chrastil model and the Mendez-Santiago-Teja model. The deviations are within the experimental uncertainty. The Peng-Robinson equation of state with two parameters van der Waals mixing rules was adopted to correlate solubility data. In general, the correlation results are well, expect for low pressure region.
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