Preparation and Characterization of Iron oxide-loaded Carbon Nanohorn

• Main Authors: Chin-Hao SU, 蘇進豪
• Other Authors: Toyoko Imae
• Format: Others
• Language: en_US
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/06417930070846172653

碩士 === 國立臺灣科技大學 === 化學工程系 === 104 === Magnetic nanoparticles for hyperthermic treatment of cancers have gained significant attention in recent years. In particular, iron oxide nanoparticles are being actively investigated to achieve highly efficient destruction of carcinogenic cells through magnetic hyperthermia treatments. However, magnetic nanoparticles, Fe3O4, tend to aggregate to form the thermodynamically favored bulk metal, which results in the loss of magnetism and dispersibility of naked magnetic nanoparticles. The highly dispersible magnetic carbon nanostructures may exhibit favorable chemical reactivity and minimal cytotoxicity. This offers promising opportunities in biomedical applications. Therefore, in this research, Fe3O4 magnetite nanoparticles with diameter under 20 nm were synthesized by using co-precipitate method. Moreover, the surface of Fe3O4 magnetite nanoparticles was coated with carbon dots (Fe3O4@C) by hydrothermal process which led to the appearance of the hydrophilic functional group (-COOH and –NH2) on magnetite surface. Additionally, acid-treated SWNH/magnetite hybrid nanoparticles were prepared by different methods which were the amidation of Fe3O4@C with acid-treated SWNHs and the direct synthesis of Fe3O4 on acid-treated SWNHs via ionic interaction. TEM images of SWNHs/Fe3O4@C demonstrated that some SWNHs were attached by the aggregate of Fe3O4@C particles. However, TEM images of SWNHs/Fe3O4 showed that SWNHs were attached to clusters of magnetite particles which completely and homogeneously surrounded SWNHs. These results reveal a possibility to improve the magnetite dispersion by using functionalized carbon nanohorns.