The study between the structural heterogeneity of polypropylene and plasticizer migration efficiency, Biodegradation study of Polycaprolactone film in the gastrointestinal tract of SD rat

• Main Authors: Jheng-Jun Jhu, 朱正均
• Other Authors: Hsieh-Chih Tsai
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/51941726031691249692

碩士 === 國立臺灣科技大學 === 應用科技研究所 === 104 === Chronic kidney disease is a large and growing problem among aging populations in Taiwan. Peritoneal dialysis (PD) is one of treatment for patients with chronic kidney disease worldwide. However, the currently dialysis bag used in peritoneal dialysis, which was made form polyvinyl chloride (PVC) blended with plasticizers. The plasticizer might be migrated from aqueous fluid and accumulated in the patient. In this project, two tacticity polypropylenes were selected instead of PVC materials for investigating the migration of plasticizer from polymer. Plasticizer, Bis(2-ethylhexyl) phthalate (DEHP), blended with isotactic and atactic polypropylene and then immersed in hot and room temperature water to study the migration of plasticizer. FT-IR result showed that the carbonyl band from DEHP exhibited in polypropylene blended samples indicated that DEHP was successfully mixed with polypropylene. From thermal gravimetric analysis, the results indicated that 32% of DEHP blended in high-molecular isotactic PP. From UV results, it also indicate that the amount of DEHP migrated from low-molecular isotactic PP more than that of low-molecular atactic PP and high-molecular isotactic PP. In conclusion, high-molecular isotactic polymer will be recommended as packing material due to low migration amount of DEHP in water. To realize the biodegradable properties of poly(ε-caprolactone) (PCL) gastrointestinal tract, the PCL films was separately implanted in stomach and intestine of rat. The PCL films was prepared from solvent casting in this study. The various PCL films were surgically implanted in Sprague Dawley rats for one month and then the biodegraded PCL films were took out for further analysis. Through weight-loss analysis of implanted PCL film at different time period, the degradation rate of PCL implanted in intestine faster than the degradation rate of PCL implanted in stomach. In addition, scanning electron microscopy results showed that the surface of PCL films implanted in stomach is rough, however the surface of PCL films implanted in intestine exhibited partial erosion. The effects of molecular weight and degree of crystallinity on the degraded PCL film were also evaluated by differential scanning calorimetry and Gel Permeation Chromatography. In stomach, since there is lack of enzyme, the degradation of PCL film was dominantly in hydrolysis process. However, the degradation of PCL film in intestine involved both hydrolysis and enzymatic process. From the analysis of molecule weight in biodegraded PCL films, the enzymatic degradation of PCL film is different from the hydrolysis degradation of PCL films.