| Summary: | 碩士 === 國立臺灣大學 === 臨床牙醫學研究所 === 104 === Tissue conditioners are often used in edentulous patients to treat lesions of the alveolar mucosa caused by ill-fitted dentures. The main problem in clinical use is the rapid loss of viscoelasticity due to the leaching of ester plasticizer and ethanol.
For extending the life span of tissue conditioner and decrease the using of bio-toxic components, our research team had used acetyl tributyl citrate (ATBC), which are non- toxic and adding hyperbranched polyester (TAH) with large molecular weight to reduce the plasticizer leaching to oral cavity and the loss of viscoelastic property. The results showed that the viscoelasticity stability of new tissue conditioners using using ATBC 78.3%, TAH 8.7% and ethanol 13% as plasticizer was better than another conventional brands. The changes in the percentage of complex modulus (G*) with time for new tissue conditioner was the smallest of all the groups. Therefore, in this study, this new tissue conditioner is the most suitable combination for tissue conditioners.
In order to explore the possibility of clinical using, the bonding failure from denture must be discussed. Our research point is the bonding strength between tissue conditioner and denture resin. We would assess the tensile bonding strength between tissue conditioners(NTU-TC, Lynal, Soft liner) in the simulations of oral cavity, immerse in 37°C distilled water, for several days(Day 0, 1, 3, 7, 14, 28). The bonding failure mode would be observed. The results showed the tensile bonding strength of all groups increase with immersion time. Except Day 0, NTU-TC had stable bonding value from Day 1 to Day 28. All samples of three tissue conditioners had adhesive failure mode. We think the new tissue conditioner(NTU-TC) had suitable bonding property with denture resin.
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