Comparative Effectiveness Analysis of Resistance Training, Endurance Training and Whole Body Vibration in Treating Sarcopenia in Elderly: Systematic Review and Network Meta-Analysis

• Main Authors: Chih-Chin Lai, 賴芝錦
• Other Authors: 簡國龍
• Format: Others
• Language: en_US
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/20529675903615201220

碩士 === 國立臺灣大學 === 流行病學與預防醫學研究所 === 104 === Background and Objectives: Sarcopenia is an age-related loss of muscle mass, muscle strength, and physical performance. Few studies have examined the relative benefits of resistance training, endurance training, and whole-body vibration through the simultaneous consideration of three diagnostic criteria: muscle mass, muscle strength, and physical performance. The purpose of this systemic review and network meta-analysis was to analyze the effects of resistance training, endurance training, and whole-body vibration on changes in muscle mass, muscle strength, and physical performance through the evaluation of lean body mass, leg extension strength, and chair-stand tests in elderly people. Methods: We combined evidence from all randomized controlled trials comparing resistance training, endurance training, and whole-body vibration with usual care among adults aged at least 60 years. The effects of exercises and usual care on muscle mass, muscle strength, and physical performance were examined. We performed a mixed treatment comparison by using generalized linear mixed models for the network meta-analysis. Results: Thirty-one randomized controlled trials involving 1405 participants were included (age range, 60–92 years). Muscle strength enhancement was greater for resistance training compared with usual care [12.8 (95% CI 8.54 to 17.0)]. Physical performance enhancement was greater for resistance training compared with usual care, and whole-body vibration was greater compared with usual care [2.63 (95% CI 1.34 to 3.93), and 2.07 (95% CI 0.49 to 3.65)]. No significant difference was observed regarding changes in lean body mass. Conclusion: Resistance training is beneficial for elderly people with outcome indicators of sarcopenia; specifically, it enhances muscle strength and physical performance. Resistance training and whole-body vibration were the two most effective exercise interventions in terms of physical performance. However, no statistically significant results were observed for resistance training, endurance training, and whole-body vibration concerning increases in muscle mass.