| Summary: | 碩士 === 國立清華大學 === 動力機械工程學系 === 104 === To date, photon radiation therapy and electron knife therapy are quite popular. However, there are still many side effects to the uninfected tissues. Therefore, through my thesis I am going to focus on the proton and hadron beam therapy, especially on the dose simulation. To achieve the goal of killing the infected tumor cells and also without influencing the surrounding normal tissues, we have to set up a mathematical model to predict the dose distribution along the beam path.
The main objective of this thesis is to build up a radiation therapy model to simulate the beam therapy in human cells and to observe the dose effectiveness. It is known that the percentage of water in human cells is about seventy to eighty percent, it is reasonable to take human cells as a water phantom cubic model in the realistic situation. Later on, by applying different kinds of beamlines such as electron knife, photon radiation, and hadron and proton particles, we can compare the dosage distribution by distribution plot simulated through the Monte Carlo simulation package Geant4.
In summary, the most ideal beamlines from the simulation results is the proton and/or hadron beam. Comparing with the electron and photon beams, the dosage of proton and hadron can be raised up to almost one hundred percent which minimizes the side effects of residual dosage on normal tissues. The main defects of the carbon beam for the hadron therapy is the fragmentation tail. However, the dose range and damage compared to the peak of the dosage is too tiny and can be ignored. The hadron therapy as well as the proton therapy are still the most effective treatment to kill the tumors nowadays.
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