| Summary: | 碩士 === 國立清華大學 === 材料科學工程學系 === 104 === This study is to investigate the detection of rhythmic electrical signals of adult Zebrafish and its larvae using both three dimensional (3D) gold microelectrode and 3D functionalized biocompatible direct-growth carbon nanotube (CNT) microelectrodes. This study also demonstrates the applicability of 3D microelectrode as a tool to study living organisms pathology in the future.
The CNTs were directly grown on 3D gold microelectrodes at 400 °C. With high surface area, capacitance and biocompatibility, 3D funtionalized CNTs improve coupling coefficient and signal-to-noise ratio. Therefore, the 3D CNTs microelectrodes reveal better potential for biosignal recording than 3D gold microelectrodes. In addition, low temperature fabrication process provides the feasibility of implementation with flexible polymer substrates.
The detected adult Zebrafish and its larvae signals were analyzed to compare the results by using different electrodes and system set-ups. The equivalent circuits were also compared for the explanation of measurement results. Furthermore, a preliminary drug test was conducted. Results show the potential application of 3D microelectrodes for all-age Zebrafish pathological Electrocardiogram (ECG) study.
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