The Effects of Tetrahydroxystilbene Glucoside on Cellular Senescence

• Main Authors: Wu, Jia Yee, 伍嘉儀
• Other Authors: Chang, Chuang Rung
• Format: Others
• Language: en_US
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/8g4hfd

碩士 === 國立清華大學 === 生物科技研究所 === 104 === Aging is a degenerative process that exhibits mitochondrial damage and dysfunction. Stilbenes such as resveratrol and THSG have demonstrated to aid mitochondria activities and prolong lifespan in model organisms. How resveratrol and THSG improve mitochondrial function and prolong lifespan is not thoroughly discussed in the past. In this study, we have examined the effects of THSG on different stages of cellular senescence, includes the cellular oxidative stress, mitochondrial morphology, and function. The results demonstrated that THSG promote senescent cell function through several pathways: (i) decrease oxidative stress in the senescent cell by reducing mitochondrial superoxide formation; (ii) promotes mitochondrial fusion, and (iii) improves senescent cell’s mitochondrial biogenesis and cellular respiration. In addition, THSG effects are only present in the senescent cell. Furthermore, THSG act as pro-oxidant during early treatment time, indicating that THSG exerts its benefits by inducing mitochondrial hormesis responses.