| Summary: | 碩士 === 國立清華大學 === 化學系 === 104 === A fluorous-tailor-designed vanadyl methoxide complex bearing p-(3′-perfluorobutyl)propoxyphenyl group at the C5 position of the salicylidene template was synthesized and then subjected to MVO3-induced (M = Na, K, Cs) self assembly to form M+-encapsulated quadruplexes 1-Na, 1-K and 1-Cs. The sodium ion of quadruplex 1-Na can be replaced by Rb+, Ag+, Hg2+ and Pb2+ to form quadruplexes 1-Rb, 1-Ag, 1-Hg and 1-Pb, and 1-Na has specific selectivity to Hg2+ with co-existence of Zn2+, Cd2+ and Hg2+. These cluster complexes were then injected into fluorous HPLC column. A systematic survey regarding the effect of the encapsulated metal ions within the alkali family and Hg2+ on the changes of interaction between fluorous-tail vanadyl complexes and fluorous column was performed by retention time on chromatography data. It was found that the retention time became longer as the size of alkali metal increased, and it’s due to the increasing of the encapsulated metal ion size from Na+ to Cs+ in the quadruplex caused its four lower rim regions of the resulting cluster (i.e, the four p-(3′-perfluorobutyl)propoxyphenyl groups) get closer and more parallel to fluorous-tail on the silica gel, thus inducing larger interaction tccess of amplified transcription of recognition o stationary phase. Notably, retention times between 1-Na and 1-Hg was deviated about 3.6 minutes, they can be distinguished clearly. This research revealed that the success of amplified transcription of recognition results from subnano to real time domain by combining fluorous-tag separation strategy with ion-specific encapsulated quadruplexes.
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