| Summary: | 碩士 === 國立中山大學 === 醫學科技研究所 === 104 === Malignant brain tumor is a serious disease. Patients treated using surgical resection, radiotherapy and chemotherapy survive, on average, for 6-24 months post-treatment. To date, surgery still is the primary treatment for brain tumor, following with chemotherapy is necessary to prevent the tumor recurrence. However, many potentially effective diagnostic or therapeutic agents are prohibited to deliver into brain by blood-brain barrier (BBB), resulting in the failure of chemotherapy.
To overcome the problems, we develop a BSA nanoparticles-incorporated temperature-sensitive hydrogel to slowly release drugs in the brain tumor. Our data showed that hydrogel could be transferred to gel from solution phase while the temperature was raised higher to 30 ℃ then sustainably released the drugs over one weeks.
This delivery system can be delivery two drug, because the different release rates of the two drugs, so it can be complementary to the difference between the two drugs and improve the therapeutic effect. As a result, it is expected to overcome the BBB, significantly reduce the side-effects and effectively prohibit the growth of residual tumor cells. In addition, the Institute produced a temperature-sensitive hydrogel has development of MRI, so it has a great help to future tracing observation.
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