| Summary: | 碩士 === 國立中山大學 === 電機工程學系研究所 === 104 === Carbon monoxide poisoning may cause brain hypoxic injury. According to previous magnetic resonance imaging report, brain atrophy could happen on surviving patients. In addition, abnormal signal intensity is possible in white matter and deep gray matter, such as globus pallidus. In this longitudinal study, voxel-based morphometry is performed by using FreeSurfer to investigate the volumetric change of brain tissues. Data collected at one and nine months after carbon monoxide poisoning, respectively, are compared by using the paired t-test. In addition, susceptibility weighted imaging, which is sensitive for the accumulation of paramagnetic substances, is also applied to monitor the appearance of the ion-rich global pallidus at several follow-up experiments.
Compared to one-month follow-up, white matter volume is found to decrease significantly at nine month (P=0.016). The decrease of white matter volume is more apparent on those patients with delayed neuropsychiatric syndrome (P=0.001). On the contrary, no significant difference is found on patients without DNS. In susceptibility weighted imaging, regional hyperintensity and dotted hypointensity can be observed on globus pallidus in some cases. However, according to the limited sample size of this study, regional hyperintensity will be accompanied by dotted hypointensity appears, but both of them are not related to the occurrence of DNS.
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