Influence of Different Hypnotics to Fracture: A Nationwide, population based study

• Main Authors: Sheng-Hsing Lan, 藍聖星
• Other Authors: Ying-Chun Li
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/81447272811692167176

碩士 === 國立中山大學 === 企業管理學系研究所 === 104 === Insomnia is one of commonest disease in modern age. There is about a quarter of all population suffered insomnia while only one fifth had their sleep disorder treated adequately. Hypnotic is one of the most powerful treatment to insomnia, but it had negative effect as well. Using hypnotics is considered related to the increasing of trauma and fracture. We aimed to figure how prescription of hypnotics affects the rate of ER visit and fracture. We used National Health Insurance Research Database as our data source. From database we selected people who take any of 3 hypnotic, naming Zolpidem, Zolpiclone and Flunitrazepam, in 2001-2003 as case group. The control group was a 3 times population sampling. The outcomes were rates of ER visit and admission for fracture. We also traced their history in past 3 months to see if any hypnotics were prescribed. More than 50 thousand people was enrolled in the case group. People of this group utilized more ER visit (2.14 to 0.99) and had more fracture (13.83% to 5.05%). The factors that affect the outcomes are age, gender, and prescription of hypnotics in past 3 months. We also figure out increments of ER visit simply for refill hypnotics in case group. Since age and prescription of hypnotics increase rates of events, we suggest clinicians take more cautions with prescribing hypnotics for elderly, and avoid of using 2 or more combination of hypnotics. The result of this study can also be helpful to future study of hypnotics control issues and medical economics studies.