| Summary: | 碩士 === 國立宜蘭大學 === 生物機電工程學系碩士班 === 104 === Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopemental disorder in children. The core clinical symptoms include inattention, hyperactivity, and impulsivity. Individuals with ADHD generally have developmental problems including poor academic, behavioral, emotional, and social functioning. The exact cause of ADHD is still unknown. A series of animal models have been proposed for ADHD research, while the spontaneously hypertensive rat (SHR) model is considered a widely accepted model. Although there is no historical record of ADHD in traditional Chinese medicine (TCM), a significant amount of empirical data are accumulated in recent years regarding the causes and the treatments of ADHD. Since people in Taiwan are used to combining western and traditional Chinese medicine, it is important to establish an interdisciplinary platform to evaluate the therapeutic efficacy of TCM treatments. In this study, Bupleurum Plus Dragon Bone and Oyster Shell Decoction, which is widely used for ADHD treatment clinically, was validated for its efficacy using the SHR model. Two different doses were given by gavage: the original dose written in Shanghan Lun, and the equivalent dose currently used for powdered herbal medicine. After 14 days of continuous treatment, SHRs of different ages showed different responses. For both doses, the treated groups showed significant increases in terms of the total distance traveled and the time spent in the central area. The increase of the time spent in the central area indicates reduced anxiety by the treatment. Yet, whether the increase in the total distance traveled is a sign of hyperactivity or reduced anxiety still needs further investigation.
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