| Summary: | 碩士 === 國防醫學院 === 公共衛生學研究所 === 104 === Background: Salivary gland tumor (SGT) is a rare disease with a largely unknown etiology. High body-mass index (BMI) or obesity predispose to several site-specific tumor, but detailed characteristics of risk of salivary gland tumor has not previously been explored. We aimed to investigate the association between BMI and salivary gland tumor.
Methods: We conducted a case-control study of totally 1845 patients aged 35–65 years, including 239 patients with pathologcally proven salivary gland tumor and 1606 controls from health management center during 2005–2014 to examine the association between obesity and the risks of salivary gland tumors. The ratio of cases and controls is about 1:7. Odds ratios (OR) and their 95% confidence interval (CI) for the association of risk factors to salivary gland tumor were calculated.
RESULTS: In cases and controls with no diabetes group, compared with people with normal weight (BMI<25 kg/m2), obese (BMI ≥30 kg/m2) had an increased risk of women salivary gland tumor (adjusted OR =4.76, 95% CI: 1.90- 11.92), benign salivary gland tumor subgroup (OR=2.15, 95% CI: 1.11- 4.18), and major salivary gland rumor subgroup (OR=2.07, 95% CI: 1.11- 3.85).
CONCLUSION: This study provides evidence that obesity is positively associated with the risk of salivary gland tumor, especially in female, benign, and major salivary gland tumor subgroup.
KEY WORDS: obesity, salivary gland tumor, body mass index.
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