Screening for latent tuberculosis infection among special group

• Main Authors: HSU HUA CHING, 徐華清
• Other Authors: Lin fu huang
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/55996682873915527040

碩士 === 國防醫學院 === 公共衛生學研究所 === 104 === Background and Objective :Taiwan new determine the annual number of cases of tuberculosis about more than eleven thousand, and about 600 to 700 people died of tuberculosis, whether new cases or number of deaths, all for the nation's first legal infectious diseases. Early detection of patients with latent tuberculosis infection, and left untreated, can prevent its conversion to active TB patients, resulting in more severe infections. The US Food and Drug Administration approval in 2007 QuantiFERON-TB Gold In-Tube test (QFT-GIT) the use, not only sensitivity and specificity are higher than the TST, and not interfere with BCG. This study aimed to investigate the employees of a latent tuberculosis infection situation and risk factors, the study period from 103 in March to September. Methods : This study is cross-sectional study, the study period from 103 in March to September , the object is at the time of the annual medical examination of employees voluntarily participate in a study. The use of structured questionnaire latent tuberculosis infection risk factors, and collect blood specimen using QFT-GIT test latent tuberculosis infection screening. Statistical methods for the multiple logistic regression. After adjusting for potential confounding factors, investigate QFT-GIT positive screening results are presented in the risk factors. Result: The study was completed questionnaires and blood tests were 803 people, including 71 positive .The results showed that the prevalence of certain employees of latent tuberculosis infection 8.84%, the OR showed that congregate subjects increased the risk of LTBI by 2.72 fold (OR=2.72,95% CI = 1.42-5.20); the OR showed that inmates with people increased the risk of LTBI by 2.49 fold (OR=2.49, 95% CI = 1.82-7.51). Conclusion: The groups of clustering in the longtime to live and work often likely to cause TB infection, it is recommended for these high-risk groups, should be regularly implement screening for latent tuberculosis infection. Keywords: screening, latent tuberculosis infection , QFT-GIT