| Summary: | 碩士 === 國立東華大學 === 化學系 === 104 === The objective of this study was to develop liposomal formulations for an anticancer drug BP in order to obtain the water-soluble stable formulations for drug delivery. In this study, BP-cyclodextrin- liposomal formulations were designed, and their characteristics including particle size, zeta potential, double-layer structure, and encapsulation efficiency were examined. It was found that the properties of the drug-containing liposomes were affected by the components of the liposomes and the preparation conditions. Up to 95% of encapsulation efficiency could be reached by the formulations with proper design and preparation processes. It was found that BP-containing cyclodextrin-liposomal formulations could significantly inhibit the proliferation of drug-resistant GBM cell line GBM22-TMZ. In addition, one of the BP-cyclodextrin-liposomal formulations was selected to perform the intranasal delivery for 60 days on the intracerebral GBM22-TMZ glioma tumor nude mice. As compared with the sham group, longer median survival time was achieved in the experimental mice treated with BP-cyclodextrin-liposomes. The results suggest that BP-cyclodextrin-liposomal formulations have potential in the development for clinical application on drug-resistant brain tumor treatment.
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