Risk of Osteoporotic Fractures in Patients with Asthma: A Population-based Perspective Cohort Study in Taiwanese People

• Main Authors: Po-Liang Chou, 周柏良
• Other Authors: Jorng-Tzong Horng
• Format: Others
• Language: en_US
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/52459788452262109412

碩士 === 國立中央大學 === 資訊工程學系在職專班 === 104 === Asthma is a common pulmonary disorder, which is characterized by chronic inflammation, airflow obstruction and bronchial hyperresponsiveness. Some study has reported that the chronic inflammation may leads to the production of cytokines, stimulating bone turnover and increased fracture risk. However, mechanisms of osteoporotic fracture in asthma disease is unclear. Currently, corticosteroids is the most effective anti-inflammatory drug for patients with asthma. When patients do not control asthma well with the low-dose ICS, they have to either increase the dosage of ICS or add the long-acting ß-agonist (LABA) or systemic corticosteroids controller medication .Thus, corticosteroids treatment is acts as an intermediary between asthma and the osteoporotic fracture, it is an important key factor. Therefore, we explore over 50 years old newly asthma patients from National Health Insurance Research Database (NHIRD), exclude some patients who affect our study and evaluate the effects of comorbidities with asthma on the osteoporotic fracture risk. Finally, we observe that patients with asthma who take the corticosteroids treatment such as ICS+LABA used group and SCS used group compared with who not use any corticosteroids, there is increase risk of osteoporotic fracture on asthma patients (HR=5.82, 95% CI=1.31-25.86, p-value=0.0205), (HR=3.24, 95% CI=1.23-8.55, p-value=0.0174) respectively.