The Rheological Properties of Invasive Cancer Cells

• Main Authors: Zhi-Qian Wu, 吳治謙
• Other Authors: 黎璧賢
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/a938yy

碩士 === 國立中央大學 === 生物物理研究所 === 104 === The purpose of this study is to investigate the rheological properties of invasive cancer cells. We use atomic force microscopy to measure the Young’s modulus of different cell types. The result shows that the more invasive the cancer cells are, the softer they will be. We also measure the complex shear modulus, and use it to calculate the loss tangent. The result shows that if the cancer cells are more invasive, they will have the tendency to be viscoelastic liquid. The cantilever perturbation by cytoplasm is measured. From the force power spectrum and the time series data of cantilever deflection, we infer that the collision frequency of active particles is higher and the cooperativity of active motion is stronger in the more invasive cancer cells. Finally, we calculate the autocorrelation function from cantilever deflection time series data and perform the model fitting. The results show that relaxation time is shorter in the more invasive cancer cells.