Physical limit to cellular signaling

• Main Authors: Lin,Fong-Fu, 林豐富
• Other Authors: Chang, Cheng-Hung
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/qa9x6n

碩士 === 國立交通大學 === 物理研究所 === 104 === Biological receptors are capable of measuring the concentration of extracellular signaling molecules. They play an important role in cross-cellular information processing. Therefore, there have been a series of studies in the past decades. However, the measurement uncertainty formulae derived in the past studies are always based on the assumption of two-state model for these receptors. This thesis is concerned with how to generalize these formulae to high-dimensional models if the kinetics of some receptor proteins cannot be described by two-state models. Furthermore, whether all high-dimensional models will predict the same measurement uncertainty if they are kinetically equivalent to each other and what is the mathematical reason for that. To answer these questions, Bialek’s formula will be taken as an example.