| Summary: | 碩士 === 國立暨南國際大學 === 應用化學系 === 104 === Micro-RNAs (miRNAs) are small non-coding RNAthat only need to pair partially to the target mRNA in order to elicit translational repression.Previously, our lab used behavioral screening to define 11 distinct dm-miRNAs from the collection of 160 UAS-miRNA lines that drove expression in elav-expressing (pan-neuronal) cells of adult Drosophila males, which can prompt inter-male courtship behavior.In my study, the underling same experimental approachto find outthe role of the individual miRNA involves the male or female fly heterosexualcourtship activity. Our result showed that 15 miRNAs affected male courtship responses and 36 miRNAs affected female courtship responses.We highlight the importance of these miRNAs in neuronal system, and expect to identify the miRNAs targets and gain molecular insights in the mechanisms of fly courtship activity.Our long-term goal is todissect sex processes at biochemical, genetic, anatomical, and behavioral levels. Such “translational” studies of the flysystems neuroscience generate clinically relevant insight into human brain function and ultimately may lead to important advances in the understanding in vertebrate.
|
|---|
