Effects of Diabetes Mellitus on Mechanical Behavior of Peripheral Nerve Tissues and Vasa Nervora under In Situ Circular Compression
碩士 === 國立成功大學 === 機械工程學系 === 104 === Ischemia of vasa nervora in peripheral nerves may be the main cause of diabetic neuropathies. Diabetic neuropathies are also related to clinical morbidity of carpal tunnel syndrome. Thus, from biomechanics perspective, study of mechanical behavior of peripheral n...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2016
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/03082780865605227003 |
| Summary: | 碩士 === 國立成功大學 === 機械工程學系 === 104 === Ischemia of vasa nervora in peripheral nerves may be the main cause of diabetic neuropathies. Diabetic neuropathies are also related to clinical morbidity of carpal tunnel syndrome. Thus, from biomechanics perspective, study of mechanical behavior of peripheral nerve tissues and vasa nervora under compression and diabetic circumstances may help understanding mechanisms of retarded blood flow in nerve. In this study, in situ compress-and-hold experiments were implemented by circular compression on sciatic nerve of rats and blood flow within vasa nervorum was observed by using Doppler optical coherence tomography (D-OCT) simultaneously. Mechanical property of nerves was determined by fitting the data from the experiments with a quasi-linear viscoelasticity (QLV) model. Cross sectional area and morphology of vasa nervorum and their variations with time were estimated from D-OCT image data using new methods. The finite element method (FEM) was utilized to simulate stress distribution and morphology changes of substructures in the nerve. Results of this study suggested diabetic nerves are more viscous in mechanical property and their vasa nervora are more vulnerable to circular compression. Results from FEM suggested that the perineurium could sustain more stress while the epineurium served as cushion under circular compression. The results also indicated there are specific regions in epineurium which sustained less stress and blood vessels in such regions had less tendency to collapse. The large blood vessels in nerve are most likely to be settled on these regions according to tissue slices. Comparison between D-OCT data and FEM results suggested that vasa nervora have auto-regulation ability.
|
|---|