Ionic Liquid-Supported Synthesis of Bacterial Peptidoglycan Analogues

• Main Authors: Chung-HuanHsu, 徐崇桓
• Other Authors: Wei-Chieh Cheng
• Format: Others
• Language: en_US
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/4n3rat

碩士 === 國立成功大學 === 化學系 === 104 === In the bacterial peptidoglycan (PGN), there are lots of unique and structurally complex biologically interesting molecules. However, it is still difficult to purify them from natural sources and directly modify them from these isolated molecules. Thus, development of new methods for preparation structurally diverse PGN analogues is an important task to chemists. In this work, there are three parts: (a) development of IL-supported synthetic routes for preparation of peptidoglycans with a phosphate moiety (b) discovery of IL-supported synthesis for preparation of glycan chains of PGN, (c) development of ionic liquid matrixes. Through our efforts, we have we have successfully developed two methods to prepared the IL-supported intermediate bearing a phosphate at the reducing end of saccharides. It is a pivotal intermediate that allows us for further construction of a pyrophosphate synthesis. In addition, we have demonstrated new IL-matrixes, which might be more convenient for IL-supported synthesis. We believe our developed conditions can accelerate the progress of IL-supported peptidoglycan synthesis in the future.