A Fenton Reaction Activable Polymersome in Ultrasound-mediated Imaging and Therapy

• Main Authors: Yi-ChingChang, 張翊菁
• Other Authors: Chen-Sheng Yeh
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/05755955687420198295

碩士 === 國立成功大學 === 化學系 === 104 === We demonstrate a successful synthesis of a theranostic polymersomes and provide a series of imaging and therapy platform in this article. We synthesis the theranostic polymersomes by double emulsion (water/oil/water) method. The core area of the polymersomes is hydrophilic, and the space between the core and outer shell is hydrophobic. The hydrophobic ligand iron oxide nanoparticles can be embedded in the hydrophobic space. Due to the component of Fe3O4 nanoparticles which provides ferromagnetic property, it can be applied as T2-negative contrast agents of magnetic resonance imaging (MRI). We can use magnet targeting the tumor site to guide the polymersomes to tumor. Combining with ultrasound irradiate, this material can get ultrasound imaging and induced ROS mediated therapy. The in vivo test provide a strong evidence for cancer treatment.