| Summary: | 碩士 === 國立中興大學 === 獸醫學系暨研究所 === 104 === Chinese stripe-necked turtle (Ocadia sinensis) is one of the most commom native freshwater turtles found in Taiwan. The pharmacological restraint for physical examinations and surgeries is necessary in them. The aim of my study was to evaluate the sedation effect of intravenous injection of alfaxalone (ALF) and the combination of alfaxalone and azaperone (ALF-AZA) with different proportions, and find out the best combination for pre-intubation sedation in chinese stripe-necked turtle. The study was performed with 16 adult chinese stripe-necked turtles, with an average weight of 1.91±0.36 kg. Turtles were then assigned to five treatment groups: ALF 2.5 mg/kg (n = 8), ALF 5 mg/kg (n = 8), ALF 2.5 mg - AZA 4 mg/kg (n = 8), ALF 2.5 mg - AZA 6 mg/kg (n = 8), repeat with the dosage of ALF 2.5 mg - AZA 4 mg/kg (n = 8). The cloacal temperature, heart rate and the anesthetic depth were recorded. The result of the study showed 25% turtles in ALF 2.5 mg/kg group could be intubated, while all turtles in other groups achieved the depth of intubation. ALF 5 mg/kg group and ALF 2.5 mg - AZA 4 mg/kg group had deep sedation with loss of head, forelimbs and hind limbs withdraw reflexes to touch and the reflexes to pinch in forelimbs and hind limbs. ALF 5 mg/kg group had the longest duration with loss of head and forelimbs withdraw reflexes to touch. ALF 2.5 mg - AZA 4 mg/kg group had the highest rate (75%) and the longest duration (17.17 ±7.00 min) of sedation, and the longest duration of hind limds analgesic phase (24.33 ±10.17 min) than other three group. There are no differences between the two ALF 2.5 mg - AZA 4 mg/kg groups. ALF 2.5 mg - AZA 4 mg/kg could be a choice for short clinical medical management and pre-intubation sedation.
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