Synthetic Studies toward the fragment of (-)-Oseltamivir:3-(buta-1,3-dien-1-yloxy)pentane
碩士 === 國立中興大學 === 化學系所 === 104 === The Diels-Alder reaction is an efficient synthetic method to synthesize 6-members ring of the (-)-Oseltamivir framework. The synthetic method is separated into diene and dienophile. This thesis is introduced to prepare the diene fragment, 3-(buta-1,3-dien-1-yloxy)p...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2016
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| Online Access: | http://ndltd.ncl.edu.tw/handle/54727481637178510388 |
| Summary: | 碩士 === 國立中興大學 === 化學系所 === 104 === The Diels-Alder reaction is an efficient synthetic method to synthesize 6-members ring of the (-)-Oseltamivir framework. The synthetic method is separated into diene and dienophile. This thesis is introduced to prepare the diene fragment, 3-(buta-1,3-dien-1-yloxy)pentane, with cis-2-butene-1,4-diol 76, 2,5-dihydrofuran 79, propargyl alcohol 81, or pentan-3-yl formate 86 through nucleophilic substitution, E1, E1CB or Wittig reaction.
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