The investigation of the risk factors on influencing the survival of colorectal cancer

• Main Authors: Cheng Shu Chen, 鄭淑貞
• Other Authors: Chao Hsien Lee
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/29668655150395176695

碩士 === 美和科技大學 === 健康照護研究所 === 104 === Abstract Background: World Health Organization (WHO) mentioned of 14.0 million new cancer cases and 820 million death cases in 2012 ( Colorectal cancer, around 69.4 million ) in the “World Cancer Report ”on 4thFebruary 2014. The Colorectal cancer ranks the third most common cancer in the world. In the report of Taiwan Health Promotion Administration Department of MOH published the top ten causes of death in June 2015, Malignant (cancer) was the top one in thirty-three years from 1982 onwards. Cancer deaths grow up to 46,094 people and total number of deaths caused by colorectal cancer was 5,603 people. The Cancer Registry Report prompted this study to raise public attentions of the risk factors for the Colorectal cancer, in order to prevent cancer occurance effectively, understanding the causes and treatment of Colorectal cancer. Purpose: To explore the impact of risk factors for colorectal cancer survival from the statistical analysis of the Cancer Registry Database. Methods: In the cancer registry database for colorectal cancer of, 869 cases of human retrospective studies in a northern Taiwan medical center during the period of 2007 and 2013. Using Kaplan-Merier survival analysis of patients and Cox forward regression analyse the overall impact of risk factors for colorectal cancer survival. Results: Total compiled cases are 869 people which includes Colorectal Cancer Stage I 190 people (21.86%), Stage II 238 people (27.39%), Stage III 303 people (34.87%) and Stage IV 138 people (15.88%). The survival rate of Stage I is 84.82%, Stage II 76.59%, Stage III 68.91%and Stage IV is 36.20%. The average overall survival rate is 71.27%.Through Cox points forward stepwise regression model analysis, age, tumor violations, distal organ metastasis, I-IV pathological stage circumferential resecting margin (CRM), K-ras, smoking, drinking present the P value (P<.05) that has a significant meaning of the prediction among the colorectal cancer patients with a higher death risk. Conclusions: The study found the age of cancer patients, deeper extent of tumor invasion, lymph node metastasis, distant organs metastasis, pathological type of ring cell carcinoma, poorly differentiated pathology, primary tumor size, Pathological ring CRM margin positive, K-ras positive, intestinal obstruction are the impacts of the colorectal cancer treatment. Patients with risk factors have higher survival rate if patients have earlier diagnosis and treatment.