| Summary: | 碩士 === 高雄醫學大學 === 香粧品學系碩士班 === 104 === Among the dendrimers, melamine based dendrimer (also called triazine
dendrimer) is potential and considering in biomedical application owing to
the simplicity and variety in its synthetic route and various products could
be easily obtained by temperature-controlling process. In the recent past,
dendrimers are being studied as drug carriers for drug delivery. In this
research, the triazine dendrimers with Piperazine and 4-
(aminomethyl)piperidine as linkers were prepared through solid phase
synthesis processes to offer generation zero (G0) to generation two (G2).
In general, our approach significantly reduced the product complexity and
also achieved the yield enhancement to 70%. In the drug encapsulation test,
there are two groups of compounds were used as guest molecules to
determine the interaction between them with host molecules, triazine
dendrimers. Group one is three common sunscreens with benzene ring and
carbochain in their structures. Another group is non-sunscreen compounds
containing thymine, kojic acid and (R)-(-)-Mandelic acid. The binding
were evaluated by isothermal titration calorimeter (iTC 200 ) and Nuclear
Magnetic Resonance (NMR), however, the binding capacities were only
determined by the chemical shift of guest molecules in NMR. The chemical
shift of sunscreens changes around -0.0010-0.013 ppm and another group
changes around -0.005-0.052 ppm. Among them, the thymine binding with
PITD-G2 through hydrogen bonding gave +0.052 ppm change to present
the strongest interaction. Therefore, it demonstrates the interaction ability
between thymine and the rigid PITD-G2 is best. This study has proved that
the design of the triazine dendrimers can be combined with the drug
molecules, and NMR can clearly determine a combination of Host-and-
Guest reaction.
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