The oxygen uptake efficiency slope in children with congenital heart disease

• Main Authors: Sih-Han Wang, 王思涵
• Other Authors: I-Hua Chu
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/67635913962395549975

碩士 === 高雄醫學大學 === 運動醫學系碩士在職專班 === 104 === Background: Maximal oxygen consumption is commonly used to evaluate cardiorespiratory fitness. However, children with congenital heart disease often cannot reach the maximum oxygen uptake during the graded exercise testing. This may be due to poor cardiorespiratory fitness and lack of motivation. Therefore, in recent years several submaximal parameters, such as anaerobic threshold, ventilation / carbon dioxide generation relations, are used to evaluate cardiorespiratory fitness. Yet, both parameters can be affected by subjects’ efforts and different testing procedures. The oxygen uptake efficiency slope (OUES) is a promising submaximal index of exercise capacity. OUES is not affected by subjects’ efforts, exercise intensity, and testing protocols, thus can be an objective measure for cardiorespiratory fitness. This parameter has been used in heart failure patients, healthy adults, and individuals with obesity. Very few studies have used OUES to assess cardiorespiratory fitness in children with congenital heart disease. Objective: This study aimed to investigate whether the OUES can be used to assess cardiorespiratory fitness in children with congenital heart disease. Methods: This is a retrospective research in which data from 2006 to 2014 were gathered and analyzed. All participants in this study were children with a diagnosis of congenital heart disease and have undergone surgeries. This study collected 9 children with Tetralogy of Fallot and 25 children with ventricular septal defect. The exercise testing protocol used was Modified Ramp Bruce protocol. Peak oxygen uptake (VO2peak) was measured and OUES100, OUES90, OUES80, OUES70 , OUES60, OUES50, OUESAT were calculated. Pearson correlation analysis was used to examine the associations between VO2peak and each percentage of OUES. Results: Overall, OUES100, OUES90, OUES80, OUES70, OUESAT, OUES60 and OUES50 were all significantly correlated with VO2peak. In children with ventricular septal defect, all OUESs were also significantly correlated with VO2peak. However, in children with Tetralogy of Fallot, none of the OUES was correlated with VO2peak. Conclusion: The results of this study suggested that OUES may provide a valid evaluation of cardiorespiratory fitness in children with ventricular septal defect, but may not be used to assess cardiorespiratory fitness in children with Tetralogy of Fallot.