| Summary: | 碩士 === 義守大學 === 醫務管理學系 === 104 === Purpose:
Cancer is the leading cause of death worldwide. Accurate localization of malignant tumor is the important part of treatment planning for the patient of cancer. Fluorine-18- fluorodeoxy glucose (18F-FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) has been proved useful for the detection, staging and restaging of several malignancies. Unfortunately, 18F-FDG PET/CT PET / CT still could not avoid the false positives and false negatives. There are some organs and tissues will have high uptake of 18F-FDG and cause false positive result, such as the inflammatory tissue, genitourinary tract, intestine, muscle, and so on. The reason of intestinal uptake of 18F-FDG may be due to constipation, increased peristalsis of gastrointestinal tract or contraction of intestinal smooth muscle. Therefore, we try to use laxatives to reduce those conditions and hope to decrease intestinal uptake of 18F-FDG. If we can use this method to reduce the intestinal uptake of 18F-FDG and eliminate the false positive of image before examination, it will assist physician to solve the difficulties of image diagnosis.
Materials and Methods:
In this study, we collect 202 subjects to divide into“ not taking laxatives group” and “taking laxatives group”. There are 109 people not taking laxatives and 93 people taking laxatives. Through the physicians of the nuclear medicine who are experienced diagnose. We count the SUV value of colon, descending colon, sigmoid colon and rectum. Then we generalize following three points: 1. Whether the gender will affect the value of each intestinal SUV. 2. Whether the age will affect the value of each intestinal SUV. 3. Whether the taking laxatives will affect the value of each intestinal SUV. The use of positron scanned images plus physiological functions of human anatomy and CT images provided interpretation of 18F-FDG in the body''s metabolic profile, using laxatives (Klean-prep), and reduce shrinkage caused by constipation or intestinal smooth muscle increase intestinal motility caused by 18F-FDG uptake increased pharmaceutically active, in order to reduce the intake of intestinal physiology, the statistical software SPSS2 descriptive statistical analysis of the distribution of the various variables. Finally, we use nonparametric analysis Kruskal Wallisru and Mann-Whitney U to confirm.
Result:
We use Mann-Whitney U (P <0.05) to test whether that gender will affect the uptake of intestinal SUV values. We found between gender and among the various intestinal SUV max all are> 0.05, regardless of whether they have used laxatives. It proves that gender does not interfere with their intestinal uptake between the SUV. It can be found that the age does not affect the reading in the intestinal SUV. We use Kruskal Wallisru test (P <0.05) to judge whether age would be interference between the value of its SUV intestinal uptake. The group is divided into three age groups, regardless of whether they have used laxatives, then we found age and among intestinal P value SUV mas between all are> 0.05. It shows that the age does not interfere with their gut SUV between intake. It can be found that the age does not affect the reading in the intestinal SUV. We use Mann-Whitney U test (P <0.05) to judge whether it would interfere with the use of laxatives affect uptake among its various intestinal SUV max values. We found between the use of laxatives and various intestinal P value SUV max are all <0.05. Unused laxatives liver SUV max (SUV max: 2.6 ± 0.3) and thigh SUV max (SUV max: 0.9 ± 0.1) and liver SUV max (SUV max: 2.6 ± 0.3) after use of laxatives and thigh SUV max (SUV max: 0.9 ± 0.1). There were no specific changes in the value of each group. It can be understood that the use of laxatives does not affect the intake of other organs SUV max values. In addition, the use of laxatives can really improve the uptake of intestinal SUV values uptake SUV max values significantly decreased (P <0.05). Thus verifiable, laxatives can make use of intestinal SUV value decreased to reduce SUV max value due to the contraction of smooth muscle of the intestinal motility and constipation and intestinal tract caused by increased and improved intestinal qualitative images.
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