Predicting the neurological sequelae for patients with CO intoxication

• Main Authors: Jui-Chi Li, 李瑞琦
• Other Authors: Chao-Wei Chou
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/9s55at

碩士 === 義守大學 === 資訊管理學系 === 104 === So far, the risk factor of the forecast neurological sequelae after carbon monoxide poisoning is controversial. In order to find the answer to this question, we conducted a retrospective case-control study which includes the patients who are poisoned by carbon monoxide from 2005 Jan 1st to 2013 Dec 31st in one of the southern Taiwan medical centers. We collected 301 patients in our study. There are 81 patients who had neurological sequelae in the case group. The control group includes 220 patients who didn’t had neurological sequelae. We collected the patients’ age, gender, past history, the cause of carbon monoxide poisoning, the exposure period, symptom, laboratory data which included the concentration of carboxyhemoglobin [COHb], hyperbaric oxygen therapy, intubation, hospital time, the length of hospital stay, and the unit of hospitalization. We use statistic software SPSS 20.0 to analysis the risk factor of the forecast neurological sequelae after carbon monoxide poisoning. The average age of case is 39.8±13.3 years old and the age of control is 38.6±13.9 years old. There are 60.5% patients of the case group are male, and 58.2% of the control group (P value=0.72). The major cause of carbon monoxide poisoning is charcoal burning (90%). Second cause is gas incomplete combusting (6%). We found that the concentration of carboxyhemoglobin [COHb] and hyperbaric oxygen therapy are both not the risk factor of the forecast neurological sequelae after carbon monoxide poisoning. We found the only independent risk factor is the exposure period of carbon monoxide after analyzing in the logistic regression model. The longer period of carbon monoxide the patients exposure, the higher possibility have the neurological sequelae. The odds ratio of patients who expose carbon monoxide more than five hours are 2.36 compare with the patients expose under three hours. Therefore, while we seek the best way of treating the carbon monoxide poisoning, we may also try to eliminate the carbon monoxide poisoning and to shorten the exposure period in the same time. The act including suicide prevention, home safety of gas consuming and the knowledge of early symptoms of carbon monoxide poisoning which may be the most effective path to solve this problem.