| Summary: | 碩士 === 義守大學 === 化學工程學系暨生物技術與化學工程研究所 === 104 === In several decades, the life of the people was greatly improved by the using the antibiotics. However, the gene mutation of pathogens was caused by the abuse of the antibiotics and this resulted in the emergence of multi-drug resistant(MDR), include methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MR-CNS), penicillin-resistant Streptococcus pneumoniae (PRSP) and vancomycin-resistant enterococcus (VRE). Therefore, strengthen propaganda security concept of using the antibiotics, and developing actively the more effective and safety of antibiotics. This is a pressing research topic.
Synthesis of 2-bromo-N-phenylacetamide derivatives by the reactions of substituted aniline and bromo acetyl bromide , then the Benzene amide derivatives were obtained by the reactions of 2-bromo-N-phenylacetamide derivatives with amines which includes the linear carbon amines, the saturated cyclic amines and the aromatic amines. The method of disk inhibition zone was used to test the antibacterial activity of these derivatives to the bacterials which include Staphylococcus aureus ATCC 6538p、Acinetobacter baumannii ATCC 19606、Pseudomonas aeruginosa ATCC 27853 and Pseudomonas aeruginosa ATCC 29260. The suppressed the inhibition zone diameter size was used to judgment antibacterial activity of phenylacetamide derivatives.
The results of experimental show the antibacterial activity of phenylacetamide derivatives as following : when substituent is an aromatic group , this derivative has a significant antibacterial activity to Staphylococcus aureus ATCC 6538p;when substituent is a linear alkyl group, this derivative has a significant antibacterial activity to Acinetobacter baumannii ATCC 19606、Pseudomonas aeruginosa ATCC 27853 and Pseudomonas aeruginosa ATCC 29260.
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